By John B. West (auth.), Jason X. -J. Yuan, Joe G.N. Garcia, John B. West, Charles A. Hales, Stuart Rich, Stephen L. Archer (eds.)

The Textbook of Pulmonary Vascular ailment combines uncomplicated clinical wisdom at the pulmonary circulatory process at degrees of the molecule, mobile, tissue, and organ with scientific analysis and therapy of pulmonary vascular ailments. cutting-edge ideas and their capability functions in learn, prognosis, and therapy of pulmonary vascular ailments also are coated. Jason X.-J. Yuan, MD, PhD is Professor of drugs, collage of Illinois at Chicago, Chicago, IL Joe G.N. Garcia, MD is Earl Banes Professor of medication and Vice Chancellor for examine, college of Illinois at Chicago, Chicago, IL Charles A. Hales, MD is Professor of drugs, Massachusetts common health center, Harvard scientific college, Boston, MA Stuart wealthy, MD is Professor of drugs, collage of Chicago, Chicago, IL Stephen L. Archer, MD is Harold Hines Jr. Professor of drugs and leader of Cardiology, college of Chicago, Chicago, IL John B. West, MD, PhD, DSc is extraordinary Professor of body structure and medication, college of California, San Diego, los angeles Jolla, CA

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Sample text

A further important advance was when Dexter and colleagues showed that it was possible to wedge the catheter in a small pulmonary artery and thereby obtain a measurement that was approximately equal to the pulmonary venous pressure [25]. 1 The Human Pulmonary Circulation: Historical Introduction Building on these studies, it soon became possible to insert catheters into the left side of the heart via a peripheral systemic artery. These procedures were combined with angiography using radio-opaque contrast material, and a key advance occurred in 1958 when Mason Sones accidentally injected contrast material into the ostium of the right ­coronary artery of a patient and was astonished to record the first coronary angiogram; the patient recovered successfully [26].

Other workers have shown differences in regional vascular conductance in dog lungs [47], and also stratified inequality of blood flow along terminal lung units [48, 49]. B. West reduced, but some inhomogeneity of pulmonary perfusion remained [50]. 5 L ongitudinal Distribution of Vascular Resistance in the Pulmonary Circulation The distribution of vascular resistance along the pulmonary circulation from the pulmonary arteries to the veins has been the subject of numerous studies and there is still not universal agreement on the results.

West, MD, PhD, DSc (Ch: 1) Distinguished Professor, Department of Physiology, University of California, San Diego, La Jolla, CA, USA Nico Westerhof, PhD (Ch: 4) Professor, Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands John Wharton, PhD (Ch: 106) Department of Experimental Medicine and Toxicology, Imperial College Healthcare NHS Trust, London, UK xxxii Martin R. Wilkins, MD (Ch: 106) Department of Experimental Medicine, Imperial College London, Hammersmith Campus, London, UK Karl H.

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