By William F. Ganong

This ebook presents a present and concise assessment of mammalian and human body structure. Examples from medical medication were built-in during the chapters to light up very important physiologic strategies. The publication contains greater than seven-hundred appealing and informative illustrations. A priceless self-study consultant, which gains content material summaries, goals, essay questions, and multiple-choice questions, is equipped on the finish of the publication and is a wonderful device for college kids whilst reviewing for the USMLE and different examinations.

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The chromosomal events that occur at the time of fertilization are discussed in detail in Chapter 23. The term "ploidy" is sometimes used to refer to the number of chromosomes in cells. Normal resting diploid cells are euploid and become tetraploid just before division. Aneuploidy is the condition in which a cell contains other than the haploid number of chromosomes or an exact multiple of it, and this condition is common in cancerous cells. Cell Cycle Obviously, the initiation of mitosis and normal cell division depends on the orderly occurrence of events during what has come to be called the cell cycle.

There is intense interest in the biochemical machinery that produces mitosis, in part because of the obvious possibility of its relation to cancer. When DNA is damaged, entry into mitosis is inhibited, giving the cell time to repair the DNA; failure to repair damaged DNA leads to cancer. The cell cycle is regulated by proteins called cyclins and cyclin-dependent protein kinases, which phosphorylate other proteins. However, the regulation is complex, and a detailed analysis of it is beyond the scope of this book.

The assembly of microtubules is facilitated by warmth and various other factors, and disassembly is facilitated by cold and other factors. The end where assembly predominates is called the + end, and the end where disassembly predominates is the - end. Both processes occur simultaneously in vitro. Because of their constant assembly and disassembly, microtubules are a dynamic portion of the cell skeleton. They provide the tracks for transport of vesicles, organelles such as secretory granules, and mitochondria from one part of the cell to another.

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