By Dilson E. Rassier (auth.), Dilson E. Rassier (eds.)
Muscle contraction has been the focal point of medical research for greater than centuries, and significant discoveries have replaced the sphere through the years. This ebook facilities totally on mechanical stories, facing strength construction and law; it gathers experiences played by way of scientists who've used diversified muscle innovations, and who've formed the sphere of muscle contraction during the previous years. beginning with theoretical methods to appreciate myosin molecule functionality and energetics, this booklet covers experimental paintings played with unmarried molecules, and discusses effects from experiences investigating uncomplicated mechanisms of contraction, utilizing (mostly so as of visual appeal) remoted sarcomeres, myofibrils, and fibers are awarded. The final chapters summarize reviews investigating the consequences of acute and persistent variations, together with weak point and muscle sickness. Muscle Biophysics represents an exceptional resource of knowledge for readers desiring to comprehend the mechanics of muscle contraction, and is an interesting choice of chapters that might with a bit of luck stimulate younger investigators to pursue study during this interesting box of research.
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Extra resources for Muscle Biophysics: From Molecules to Cells
The absence of a real plateau of the length–tension relation can be explained by the fact that the thick and thin filaments are not constant in length and, furthermore, that there is normally some staggering (longitudinal misalignment) of the filaments within the A and I bands in a given fiber cross-section (see further Edman and Reggiani 1987). To this may be added that the force producing capacity may differ by several (up to 10) % along the length of the muscle fiber (Edman et al. 1985). Taken together these findings imply that one or more regions of the fiber are actually capable of producing a somewhat greater force than that recorded from the fiber as a whole within the “plateau” of the length–tension relation (see Edman and Reggiani 1987).
J Physiol 96:54–64 Lännergren J, Hoh JFY (1984) Myosin isoenzymes in single muscle fibres of Xenopus laevis: analysis of five different functional types. Proc R Soc Lond B 222:401–408 Lee EJ, Herzog W (2008) Residual force enhancement exceeds the isometric force at optimal sarcomere length for optimized stretch conditions. P. Edman Lou F, Sun Y-B (1993) The high-force region of the force–velocity relation in frog skinned muscle fibres. Acta Physiol Scand 148:243–252 Maréchal G, Plaghki L (1979) The deficit of the isometric tetanic tension redeveloped after a release of frog muscle at constant velocity.
By contrast, unloaded shortening does not result in force depression and the sarcomere pattern after unloaded shortening is not markedly different from that of a fixed-end tetanus. From Edman et al. (1993) The following observations were made: 1. The force deficit after loaded shortening is quantitatively related to the variation in sarcomere shortening along the length of the fiber. 15. 2. 16). 16, the recovery of force after relaxation was associated with the reappearance of a quite uniform sarcomere pattern along the fiber.