By Dennis W. Ross M.D., Ph.D. (auth.)
Scientists now remember the fact that melanoma is a genetic illness and slicing -edge molecular remedies are making their approach from the laboratory into medical perform. advent to Oncogenes and Molecular melanoma drugs offers the health professional with an exceptional figuring out of molecular biology and its purposes for the prognosis and therapy of melanoma. The ebook stories the fundamental molecular ideas and the fundamental rules of melanoma medication, together with controls of mobile progress and senescence, carcinogenesis, tumorogenesis, and epidemiology. the second one a part of the e-book supplies scientific examples to illustrate the elemental technological know-how rules, together with chapters on leukemia, colon melanoma, and breast melanoma. A bankruptcy on molecular diagnostics and screening plus a bankruptcy on new molecular anti-cancer treatments provide the reader a glance at present state-of-the-art treatments in addition to because the way forward for molecular melanoma drugs. an invaluable thesaurus defines new terminology at-a-glance. creation to Oncogenes and Molecular melanoma drugs is for all physicians looking a greater knowing of the trendy molecular rules of melanoma medication. Written in a simple, conversational layout, this article is going to be welcomed via all physicians desirous to sharpen their very own knowing of molecular melanoma medication in addition to to aid them offer sufferers with balanced info at the advances and obstacles of present therapy options.
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Extra resources for Introduction to Oncogenes and Molecular Cancer Medicine
Oncogenes: Control of Cell Growth and Senescence Cancer Genome Anatomy Project (CGAP). gov/ncicgap. HRAS Tronick SR, Aaronson SA. Oncogenes. In: Cossman J, ed. Molecular Genetics in Cancer Diagnosis. New York: Elsevier; 1990:29-48. Weinberg RA. Molecular Mechanisms of Carcinogenesis. In: Leder P, Clayton DA, Rubenstein E, eds. Introduction to Molecular Medicine. New York: Scientific American; 1994:253-276. " This is an oversimplification of the myriad of molecular functions under the control of these genes.
The corresponding proto-oncogene, c-src was first discovered in chickens that developed sarcomas when infected with the retrovirus. Not all retroviruses carry a viral oncogene. For example, the human immunodeficiency virus, HIV, has only the GAG, POL and ENV genes. The genome of a retrovirus is very minimal. The virus has a life cycle within the cell that takes advantage of the cell's genes to do what the virus cannot do alone. 5 demonstrates the life cycle of a retrovirus. The virus has a glycoprotein envelope (env) surrounding a capsid (gag) that in tum encloses the RNA genome.
The genetic sequence of the human c-myc oncogene is only 1% different than a mouse. Yet, there is a 10% difference in the base pairs of the hemoglobin genes in man and the mouse. Why is there this conservation of the oncogene structure throughout evolution? Perhaps oncogenes are already in a compact, essential form so that most mutations do not survive. Another possible mechanism is a "correction" occurs when the gene passes through a viral form. There is still much to be discovered about oncogenes.