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1 where it can be seen that CR-LIPE halved the rate of progression of diabetic nephropathy to end stage renal disease (ESRD) (Fig. 1, top) and doubled organismal survival (Fig. 1, bottom). These outcomes were independent from the usual predictors of chronic disease progression and death, such as age, gender, angiotensin system inhibitors use, blood pressure, HbA1C, etc. (Table 3) and consistent with findings from calorie and sucrose restricted rat studies. 02. 05. y sucrose-restricted controls (Bras and Ross, 1964).

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Proc. Natl. Acad. Sci. USA 96, 10857–10862. , 1995. Glycation of metal containing proteins such as Cu-Zn SOD, ceruloplasmin and ferritin: possible implications for DNA damage in vivo. Contrib. Nephrol. 112, 18–23. , 1989. Food restriction retards body growth and prevents end-stage renal pathology in remnant kidneys of rats regardless of protein intake. Lab. Invest. 60, 184–195. , 1985. Ferritin and superoxide-dependent lipid peroxidation. J. Biol. Chem. 260, 3275–3280. , 1993. The effect of iron deficiency on skeletal muscle metabolism of the rat.

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