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Extra info for Energy Metabolism and Lifespan Determination
1 where it can be seen that CR-LIPE halved the rate of progression of diabetic nephropathy to end stage renal disease (ESRD) (Fig. 1, top) and doubled organismal survival (Fig. 1, bottom). These outcomes were independent from the usual predictors of chronic disease progression and death, such as age, gender, angiotensin system inhibitors use, blood pressure, HbA1C, etc. (Table 3) and consistent with ﬁndings from calorie and sucrose restricted rat studies. 02. 05. y sucrose-restricted controls (Bras and Ross, 1964).
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