By Thomas Sutula, Asla Pitkanen (Eds.)
What are the implications, if any, of repeated short seizures which are the defining function of epilepsy? an organization solution to this query has been strangely elusive for quite a few purposes. sincerely there's a subset of sufferers who seem to tolerate seizures with rather restricted long term results, and never all sufferers are destined to growth to intractability with common seizures and incapacity. This variability and person susceptibility has made it tricky to make statements that particularly follow to the whole variety of individuals with epileptic issues, whose problems span a vast spectrum from light with very good keep watch over and few barriers, to serious with a number of day-by-day seizures and reported incapacity that has effects on employment, academic functionality, an own life.This quantity seeks to discover the spectrum of serious to extra refined harm that could be a outcome of seizures. The contributing authors have addressed those questions and similar matters utilizing a number of tools in experimental types and in sufferers with epilepsy.
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Extra resources for Do seizures damage the brain
K. (1968) Fine structural and cytochemical analysis of the staining of synaptic junctions with phosphotungstic acid. J. Ultrastruct. , 22: 361-375. H. (1992) How inaccurate is the Abercrombie correction factor for cell counts?. , 15:211-212. H. (1993) An unbiased correction factor for cell counts in histological sections. J. Neurosci. Methods, 49:133140. E. A. (1996) Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J. Comp. , 364: 3-16. Colonnier, M.
Not only are their dimensions small relative to section thickness, but also one can reasonably treat them as spherical or ovoid objects that are generally not oriented relative to section plane, or that can be measured in more than one section plane if there is reason to suspect some orientation of 'flattened' vesicles. The extent to which a section through a part of a vesicle may be invisible in an electron micrograph will depend on the size and the nature of the vesicle, but arriving at a determination of this particular 'lost caps' problem may prove elusive.
C) When the section is viewed through the microscope from above, a profile count will, on average, represent cells having a unique point (top, bottom or some other, theoretical, unique central point) in a thickness of the original tissue equivalent to T + h. That is, the profile count over-estimates the cell number by a factor of T + h / T . (D) If, for the measurement of h and T sections are re-cut perpendicular to the original section plane, then, if there is further shrinkage during this second process of cutting (which may require re-embedding), then, provided that the shrinkage acts equally on all parts of the section, for calculating the Abercrombie correction factor, no further correction is required, since the ratio T / ( T + h) = s T / ( s T + sh), where s represents the degree of shrinkage.