By Nicole M. Lauzon, Firoz Mian, Ali A. Ashkar (auth.), John D. Lambris (eds.)

Innate Immunity has lengthy been considered as the non-specific arm of immune reaction, appearing instantly and in a typical manner, to safeguard the host from infections. within the put up genomic period, our wisdom of the innate immune process is enriched by means of findings at the specificity of innate immune reactions in addition to to novel features that don't strictly correlate with immunological protection and surveillance, immune modulation or irritation. a number of stories point out that molecules concerned with innate immunity exert features which are both extra complicated than formerly concept, or cross well past the innate immune personality of the system.

The creation of high-throughput structures for genome and proteome-wide profiling, including the large volume of uncooked genetic details that has amassed within the databases, have stirred new expectancies in biomedical learn. they've got led scientists to revisit confirmed organic platforms from an international and integrative point of view. Innate Immunity learn is now confronted with the problem of attempting to combine remoted biochemical pathways into advanced gene and protein regulatory circuits. during this recognize, scientists from all over the world convened on the 4th overseas convention on Innate Immunity (June four - nine, 2006), in Corfu, Greece to debate fresh advances during this quick evolving field.

This quantity represents a suite of issues on common killer cells, mast cells, phagocytes, toll like receptors, supplement, host security in vegetation and invertebrates, evasion recommendations of microorganisms, pathophysiology, protein buildings, layout of therapeutics, and experimental methods mentioned through the conference.

Show description

Read or Download Current Topics in Innate Immunity PDF

Best science (general) books

The Evolution of Parasitism - A Phylogenetic Perspective

Parasitology maintains to learn from taking an evolutionary method of its learn. Tree building, character-mapping, tree-based evolutionary interpretation, and different advancements in molecular and morphological phylogenetics have had a profound impact and feature shed new gentle at the very nature of host-parasite relatives and their coevolution.

Mountains: Sources of Water, Sources of Knowledge (Advances in Global Change Research, 31)

This booklet addresses the most important demanding situations in assuring globally sustainable water use. satirically, water assets were pointed out either as too abundant, generating significant mess ups, and more and more liable to shortages. Addressing either one of those points calls for awareness to actual hydrological tactics in addition to human actions that have an effect on water offer and insist.

Advances in Electronic Business, Volume I

Advances in digital company advances the certainty of administration equipment, details expertise, and their joint program in company methods. The functions of digital trade draw nice awareness of the practitioners in employing electronic applied sciences to the buy-and-sell actions.

El azar y la necesidad (Ensayo sobre la filosofía natural de la biología moderna)

Ensayo sobre l. a. filosofía normal de los angeles biología moderna publicado originalmente en 1970 por Jacques Monod, Premio Nobel de Medicina en 1965. Este biólogo francés formuló el teorema de que, si en cualquier proceso se suprime l. a. inspiration de finalidad, las cosas suceden por una combinación de azar y necesidad.

Additional info for Current Topics in Innate Immunity

Example text

590, 89-101. , Moretta, L. and Moretta, A. (2005) IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors. J Immunol. 174, 3992-3998. , Koszinowski, U. and Rocken, M. (2003) Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses. Immunity. 19, 561-569. Moretta, A. (2002) Natural killer cells and dendritic cells: rendezvous in abused tissues. Nat Rev Immunol. 2, 957-964. Moretta, A.

Borg and Jamie Rossjohn, Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia, 3800. 2 Lars Kjer-Nielsen and James McCluskey, Department of Microbiology and Immunology, The University of Melbourne, Victoria, Australia, 3010. 1 Introduction CD1d is a non-polymorphic antigen-presenting molecule that is structurally related to the MHC class I molecule. CD1d molecules are heterodimers that are composed of a heavy chain that is non-covalently associated with β2-microglobulin (β2m).

2004) APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA. J Immunol. 172, 138-143. , Moretta, L. and Moretta, A. (2004) CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc Natl Acad Sci U S A. 101, 1011610121. Spaggiari, G. , Zocchi, M. , Moretta, L. and Poggi, A. (2001) NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46.

Download PDF sample

Rated 4.91 of 5 – based on 43 votes