By David A. Walker, Giorgio Perilongo, Jonathan A. G. Punt, Roger E. Taylor

The looks of this finished, evidence-based evaluate of mind and spinal tumors in youngsters is particularly well timed. The content material comprises targeted insurance of the prognosis, scientific administration, after care and tracking, and underlying biology of mind and spinal tumors in teenagers. foreign in process, associated with the foreign Society of Paediatric Oncology, and numerous multi-centre scientific trials it displays some of the methods to administration that experience arisen around the globe.

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A pioneer of neurosurgical anaesthesia. Anaesthesia 1983; 38:1214–16. 24 MacIver IN, Frew IFC, Matheson JG. The role of respiratory insufficiency in the mortality of severe head injuries. Lancet 1958; 1:390–3. 12 Historical basis of neuro-oncology 25 Monro AS. Observations on the Structure and Function of the Nervous System. Edinburgh: W. Creech & Johnson, 1783. 26 Kocher T. Chirurgische Operationslehre. Jena: G. Fischer, 1892. 27 Kocher T. Text-book of Operative Surgery, 3rd English edn. Authorised translation from the 5th German edn.

Early studies on the value of chemotherapy in brain tumors involved a series of single phase II studies aimed at investigating the chemosensitivity of neoplasms to different agents. Based on these studies, a large number of drugs have been shown to be active against brain tumors, including vincristine, procarbazine, etoposide, carmustine, cyclophosphamide, dibromodulcitol, cisplatin, carboplatin, and thiotepa. The comparative rarity of childhood brain tumors makes multi-institutional or international studies imperative for proper assessment.

Arch Psychiatry 1901; 34:303–4. 14 Cushing H. The special field of neurological surgery. Bull Johns Hopkins Hosp 1905; 16:77–87. 15 Horsley V. On the technique of operations on the central nervous system. Br Med J 1906; 2:411–23. 16 Von Eiselsberg AF, Ranzi E. Ueber die chirurgische Behandlung der Hirn- und Ruckenmarkstumoren. Arch Klin Chir 1913; 102:309–468. 17 Dandy WE, Blackfan KD. Internal hydrocephalus, an experimental, clinical, and pathological study. Am J Dis Child 1914; 8:406–82. 18 Heuer G, Dandy W.

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