By S.K. Malhotra

In response to the large ambitions set for the serial booklet of Advances in Structural Biology, quantity 6 includes exhaustive articles from specialists in various parts of biomedical learn. the typical thread one of the a variety of articles is their relevance to the functions of phone biology to human overall healthiness.

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Extra resources for Advances in Structural Biology, Volume 6 (Advances in Structural Biology)

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50 51 Insulin Signaling in Insulin-Resistant States . . . . . . . . . . . . . . 52 A. Gene Knockout Models . . . . . . . . . . . . . . . . . . . . 52 B. Animal Models of Diabetes and Insulin Resistance . . . . . . . . . 54 C. H u m a n Obesity and Type 2 Diabetes . . . . . . . . . . . . . . . 55 Advances in Structural Biology, Volume 6, pages 41-64. Copyright 9 2000 by JAI Press Inc. All rights of reproduction in any form reserved.

48 48 B. IRS Proteins . . . . . . . . . . . . . . . . . . . . . . . . C. Phosphatidylinositol 3-Kinase . . . . . . . . . . . . . . . . . 50 D. E. Akt . . . . . . . . . . . . . . . . . . . . . . . . . . . . Glut4 . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 51 Insulin Signaling in Insulin-Resistant States . . . . . . . . . . . . .

Interaction with activated receptor leads in turn to phosphorylation on specific tyrosine residues of IRS proteins. Tyrosine phosphorylated IRS proteins are targeted by a number of different intracellular proteins that have in common a specific domain homologous to Src: the Src homology-2 (SH2) domain (Wandless, 1996). In this manner, IRS proteins can activate diverse intracellular processes. In skeletal muscle, this results in stimulation of 2 major events: (1) glucose metabolism and (2) mitogenesis.

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