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Quantity sixty one of "Advances in melanoma examine" comprises assurance of the subsequent: molecular ways to melanoma remedy, radiation resistance, melanoma prevention study trials, mammalian gene amplification, retinoblastoma gene functionality, molecular genetic foundation of breast melanoma, and tumour promoting through okadaic acid type compounds.

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Alberts, D. , Buller, M. , Atwood, J.. , and Meyskens, F. , Jr. (1990). J. Natl. Cancer Inst. 82, 1280-1285. Benson, A. , and Rademaker, A. (1992). Proc. Am. Sot. Clin. Oncol. 11, 145. Bertram, J. , Kolonel, L. , and Meyskens, F. , Jr. (1987). Cancer Res. 47,3012-3031. , Paganelli, G. , and Barbara, L. (1990). Cancer Res. 50, 1156-1 159. Block, G. (1991). J. Clin. Nufr. 53, 270s-282s. Boone, C. , Kelloff, G. , and Malone, W. F. (1990). Cancer Res. 50, 2-9. Boring, C. , Squires, T. , and Tong, T.

The primary treatment of low-stage breast cancer is surgery. Following surgery, adjuvant hormonal treatment or adjuvant chemotherapy may be considered. Large prospective studies have shown that such adjuvant treatment results in improved prognosis for patients with operable breast cancer (Early Breast Cancer Trialists’ Collaborative Group), 1992a, b). Although the presence of tumor metastases in axillary lymph nodes is generally used as a selection criterium for adjuvant therapy, a proportion of lymph node-positive tumors will not develop distant metastases and may therefore be overtreated.

Kessler, J. , and Meyskens, F. , Jr. Cancer Treat. Rep. 71, 391405. Love, R. R. J. Natl. Cancer Inst. 82, 18-2 I. Malone, W. F. J. Clin. Nutr. 53, 305s-313s. , Kelloff, G . J.. Boone, C. , and Nixon, D. W. Preu. Med. 18,553556. McDonald, C. , and Stewart, H. J. Br. Med. J . 303, 435-437. McGurrin, J. , Doria, M. , Dawson, P. , Stein, H. 0.. and Franklin, W. A. Cancer 59, 1744- 1750. Moolgavkar, S. , and Luebeck, E. C. Natl. Cancer Inst. 84, 610-618. Moon, R. , and Mehta, R. G. Preu. Med. 18, 576-591.

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