By George F. Vande Woude (ed.), George Klein (ed.)

A part of a serial which provides finished reports on advances within the wide box of melanoma study. This quantity covers all points of the molecular foundation of human melanoma, discussing such issues as viral interplay with lymphocytes; tumour oncogenesis, rejection and eradication.

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Epstein and B. G. ), pp. 321-337. Springer-Verlag, Berlin. Epstein, M. , and Achong, B. G. (1979b). In “The Epstein-Barr Virus’’ (M. A. Epstein and B. G. ), pp. 1-22. Springer-Verlag, Berlin. Ernberg, I. (1989). Adv. Viral Oncol. 8, 203-214. , Fu, H. , et al. (1988). Znt. J. Cancer 42, 329-338. , Rhim, J. , and Klein, G. (1990a). Nature(London) 345,447-449. , and Rymo, L. (1990b). Proc. Natl. Acad. Sci. A. 87, 7390-7394. Farrell, P. J. (1989). Adv. Viral Oncol. 8, 103-132. , and Kieff, E. J. Virol.

Many of the growth factors in this family are thought to be synthesized as transmembrane precursors. , 1985). It is thus likely that the EGF, VGF, amphiregulin, and HB-EGF precursors are all able to interact productively with their receptors on neighboring cells, without actual release of the soluble growth factor. , 1989). , 1990). The proteolytic cleavage of these transmembrane forms into soluble growth factors may be subject to regulation. Also in these cases it is likely that the cell surface-linked forms of the precursors can interact with the cell surface receptors on the same or on neighboring cells, thus resulting in a highly localized mitogenic stimulation of the target cells.

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